Crystagen
Khavinson tripeptide bioregulator (Glu-Asp-Pro) targeting the immune system — studied for restoring immune cell differentiation and normalizing immune function in aging.
🔬 Mechanism of Action
Crystagen (Glu-Asp-Pro, EDP) is a tripeptide bioregulator targeting the immune system broadly. It regulates gene expression in immunocompetent cells — lymphocytes, macrophages, and NK cells — promoting differentiation, functional activity, and balanced cytokine production.
Crystagen modulates both innate and adaptive immunity, normalizing immune cell ratios and restoring immune competence in immunosuppressed subjects. It is considered a broader immune bioregulator than Vilon (which specifically targets thymus).
Source: PMID: 12677266
📜Background & History
Crystagen (Glu-Asp-Pro) is the broad-spectrum immune bioregulator in Khavinson's system, complementing thymus-specific Vilon. It modulates both innate and adaptive immunity.
🎯 Research Use Cases
- ✓Broad immune restoration
- ✓NK cell and macrophage activation
- ✓Immune normalization in chronic infection
- ✓Complement to Vilon in comprehensive immune protocols
💉 Dosing Protocol
| Typical Dose | 10-20 mg/day (oral) or 1-2 mg SC |
| Frequency | 1× daily for 10-30 day cycles |
| Half-Life | ~30 minutes (estimated) |
| Common Vial Sizes | 5 mg, 10 mg |
🧪 Reconstitution Example
⚠️Safety & Considerations
Standard 10-30 day Khavinson cycles. Well tolerated. Avoid in autoimmune conditions. Oral administration available.
⚡Interactions & Contraindications
Avoid in autoimmune conditions. Standard Khavinson cycling protocol.
🔗Synergies & Common Stacks
Crystagen (broad immune) + Vilon (thymus-specific) = comprehensive immune restoration targeting both innate/adaptive immunity and T-cell maturation.