GHRP-2
More potent GH secretagogue than GHRP-6 with less appetite stimulation.
🔬 Mechanism of Action
GHRP-2 is a synthetic hexapeptide and second-generation growth hormone releasing peptide. It is the most potent of the GHRP family for GH release. Like GHRP-6, it activates the ghrelin receptor (GHS-R1a), but with a higher binding affinity. GHRP-2 produces stronger GH pulses than GHRP-6 with a moderately lower appetite stimulation effect (though still greater than Ipamorelin).
GHRP-2 also elevates cortisol and prolactin more than Ipamorelin but less than Hexarelin. It does not exhibit desensitization at standard doses over typical cycle lengths.
Source: PMID: 9003422
📜Background & History
GHRP-2 (Pralmorelin) is the most potent stimulator of the GHRP family. It was extensively studied as a diagnostic tool for GH deficiency and reached clinical trial stage in Japan (Kaken Pharmaceutical) in the early 2000s. Its higher binding affinity for GHS-R1a versus GHRP-6 translates to 20–30% greater peak GH release. The moderate appetite stimulation (lower than GHRP-6) and stronger GH output make it popular for performance-focused protocols.
🎯 Research Use Cases
- ✓Maximum GH pulse output for performance and anabolic goals
- ✓GH deficiency testing (clinical diagnostic use)
- ✓Body composition optimization with moderate appetite increase
- ✓Recovery protocols requiring aggressive GH stimulation
💉 Dosing Protocol
| Typical Dose | 100-300 mcg/injection |
| Frequency | 2-3× daily |
| Half-Life | 15-60 minutes |
| Common Vial Sizes | 5 mg |
🧪 Reconstitution Example
⚠️Safety & Considerations
Research peptide. Moderately stimulates appetite, cortisol, and prolactin. Less appetite stimulation than GHRP-6 but more than Ipamorelin. Use on an empty stomach.
⚡Interactions & Contraindications
Greater cortisol elevation than Ipamorelin — not ideal for chronic stress or adrenal fatigue contexts. Prolactin elevation may affect libido/sexual function in some users. Empty stomach required for effective dosing.
🔗Synergies & Common Stacks
Most potent GHRH+GHRP stack for raw GH output. Best for anabolic or aggressive recovery protocols where cortisol elevation is acceptable.
