Cortagen
Khavinson tetrapeptide bioregulator (Ala-Glu-Asp-Pro) targeting brain cortex tissue — studied for neuroprotection, cognitive restoration, and cortical neuron gene regulation.
🔬 Mechanism of Action
Cortagen (Ala-Glu-Asp-Pro, AEDP) is a tetrapeptide bioregulator targeting brain cortex neurons. It interacts with DNA in cortical cells to regulate expression of genes encoding neurotrophic factors (BDNF, NGF), antioxidant enzymes (SOD, catalase), and synaptic plasticity proteins.
Animal studies showed Cortagen protects cortical neurons against ischemic and oxidative damage, reduces infarct volume in experimental stroke by 30-40%, and improves spatial memory in aged rats. It is part of the Khavinson CNS bioregulator family alongside Pinealon (pineal) and Cerluten (brain extract).
Source: PMID: 18402693
📜Background & History
Cortagen (Ala-Glu-Asp-Pro) targets brain cortex neurons — part of Khavinson's CNS bioregulator triad alongside Pinealon (pineal) and Cerluten (brain extract). Animal studies showed 30-40% reduction in experimental stroke infarct volume.
🎯 Research Use Cases
- ✓Neuroprotection
- ✓Cognitive support in aging
- ✓Post-stroke recovery
- ✓Neurodegenerative disease prevention
💉 Dosing Protocol
| Typical Dose | 10-20 mg/day (oral/nasal) or 1-2 mg SC |
| Frequency | 1× daily for 10-30 day cycles |
| Half-Life | ~30 minutes (estimated) |
| Common Vial Sizes | 5 mg, 10 mg |
🧪 Reconstitution Example
⚠️Safety & Considerations
Standard Khavinson protocol applies. 10-30 day cycles. No significant adverse effects documented. Can be combined with Pinealon for comprehensive CNS support. Oral or injectable.
⚡Interactions & Contraindications
Standard Khavinson protocol. Compatible with most other bioregulators and nootropic peptides.
🔗Synergies & Common Stacks
Cortagen (cortical neurons) + Pinealon (pineal gland) = comprehensive CNS bioregulator support for both daytime cognition and sleep/circadian function.
Cortagen (synthetic tetrapeptide) + Cerluten (brain Cytomax extract) = layered CNS support through targeted + broad-spectrum peptide approaches.