CalcMyPeptide
Khavinson BioregulatorAlso known as: Bonomarlot A-20, Bone Marrow Cytomax, A-20 Bioregulator

Bonomarlot

Khavinson A-20 natural peptide complex derived from bone marrow tissue — supports hematopoiesis, immune cell precursor production, and age-related decline in bone marrow function.

Half-Life
~30 minutes (estimated)
Dose Range
1-2 capsules/day
Frequency
1-2× daily for 10-30 day cycles
Vial Sizes
N/A (oral)

Chemical Profile

Formula
Polypeptide extract (Bone Marrow tissue, <5 kDa)
Molecular Wt
Mixture (<5 kDa, short-chain di- and tripeptides)
Half-Life
Variable (oral peptides absorbed via GI tract)
Bioavailability
Oral capsules (10 mg active peptides per capsule)
CAS Number
N/A (biological extract, not a single compound)
PubChem ID
N/A
Developer
Prof. Vladimir Khavinson & St. Petersburg Institute of Bioregulation
Year Developed
1980s (military-funded research, declassified 1990s)

Mechanism of Action

Bonomarlot (A-20) is a natural Cytomax — a purified polypeptide complex extracted from the bone marrow tissue of young calves using Professor Vladimir Khavinson's patented low-temperature filtration process. The resulting short-chain peptides (under 5 kDa, free of any DNA fragments or immunogenic material) act as tissue-specific epigenetic regulators for the hematopoietic system. **How It Works at the Cellular Level** Bone marrow is the body's blood cell factory — throughout your life it produces red blood cells (oxygen transport), white blood cells (immunity), and platelets (clotting) on demand. After age 35–40, this output begins declining measurably. By age 60, hematopoietic stem cell activity and bone marrow reserve can drop by 30–50%, contributing to immunosenescence, fatigue, and anemia. Bonomarlot's peptides penetrate hematopoietic stem cell and stromal cell nuclei, binding to specific chromatin regions to unwind heterochromatin and re-activate gene promoters that have been progressively silenced by epigenetic aging. The result is restoration of normal protein synthesis in bone marrow precursor cells — effectively reversing key aspects of age-related marrow decline without introducing exogenous hormones or synthetic molecules. **Known Peptide Stack Roles** Khavinson's clinical protocols recommend Bonomarlot in what he calls the "body detox" stack (A-6 Vladonix + A-7 Svetinorm + A-8 Endoluten + A-20 Bonomarlot), targeting full immune and metabolic restoration. It is also included in respiratory, locomotor, and recovery-focused stacks. **How Cytomaxes Differ from Synthesized Peptides** Synthesized peptides like Crystagen target a single molecular pathway and produce rapid, intense effects lasting 1.5–2 months. Cytomaxes like Bonomarlot contain a spectrum of related peptide molecules that work more gradually, producing effects that accumulate over months and persist long after the course ends — often 4–6 months of benefit from one 30-day protocol.

Source: PMID: 12677266

Dosing Protocol

Typical Dose1-2 capsules/day
Frequency1-2× daily for 10-30 day cycles
Half-Life~30 minutes (estimated)

Dosing Protocols

Mini-Course / General Preventive (1 box)

Dose
2 capsules (20 mg)
Frequency
Once daily for 10 days (20 caps total = 1 box)
Note: Per Vita-Stream/Khavinson protocol: the standard mini-course. For general support, repeat every 6 months. If greater support is needed, repeat every 2–3 months. Take 30 minutes before meals.

Full Monthly Course (ages 40–50)

Dose
2 capsules (20 mg)
Frequency
Twice daily for 30 days (120 caps total = 2× 60-cap boxes)
Note: Full 30-day bi-annual course recommended from age 40–45. After 50, consider 3 courses/year. Often combined with Vladonix (A-6, thymus) and Ventfort (A-3, blood vessels) for complete immune-cardiovascular axis support. Take 30 minutes before meals (morning + evening doses).

Intensive / High-Need Protocol

Dose
2 capsules (20 mg)
Frequency
Twice daily, repeated monthly as needed
Note: For significant immune decline, post-illness recovery, or oncology support contexts (physician supervision required). Combine with Endoluten (A-8) and Svetinorm (A-7) for the full "body detox" stack. Maximum recommended: 4 capsules/day (40 mg).

Administration

Route
Oral capsules (available in 20-cap and 60-cap boxes)
Timing
30 minutes before meals. Standard: 2 caps once daily. Intensive: 2 caps morning + 2 caps evening.
Fasting Required?
Yes — inject on an empty stomach

Expected Timeline

Days 1–7
Peptides begin binding to hematopoietic stem cell chromatin; initial gene expression shifts noted in preclinical studies.
Weeks 2–4 (during course)
Normalization of bone marrow protein synthesis profile underway. Users report improved energy and immune vitality.
Months 1–3 (post-course)
Peak hematopoietic output benefit; CBC values may show improved RBC, WBC, and platelet counts if baseline deficits existed.
Months 3–6
Sustained immunological benefit. Long-lasting epigenetic changes persist well beyond the supplementation window, per Khavinson's longitudinal data.

Who Is It For?

Bone Marrow / Hematopoietic Health

High

Primary target organ. Supports red and white blood cell precursor production. Relevant for age-related anemia, immune decline, and bone marrow fatigue.

Immune System Support

Moderate

Bone marrow is the source of all immune cell precursors. Bonomarlot supports the upstream factory for lymphocytes, monocytes, and granulocytes.

Post-Chemotherapy Recovery

Moderate

Khavinson's protocols have been used in Russian oncology support contexts for marrow recovery after cytotoxic treatment. Consult physician.

General Longevity / Anti-Aging

Moderate

Part of Khavinson's core anti-aging stack. Bone marrow decline is a key driver of systemic aging; Bonomarlot addresses this upstream.

Athletic Recovery & Endurance

Low

Better RBC production can improve oxygen carrying capacity. Some endurance athletes use hematopoietic support for altitude training recovery.

Safety & Considerations

Bonomarlot has been used in Russian gerontology and clinical practice for over 40 years with an excellent safety record. As a natural glandular Cytomax, it contains no synthetic analogs, no hormones, and no immunogenic or mutagenic material (confirmed by the strict <5 kDa molecular weight filtration process). Contraindications per manufacturer: individual intolerance of components, pregnancy, and lactation. As with all peptide bioregulators, consult a physician before use if you are undergoing active cancer treatment or taking immunosuppressive medications. Storage: Keep in a dry, dark place between +2°C and +25°C. Do not freeze.

Dosing Quick Reference

Bonomarlot— Dosing Guide
Dose Range
1-2 capsules/day
Half-Life
~30 minutes (estimated)
Frequency
1-2× daily for 10-30 day cycles
Route
Oral
Khavinson Bioregulatorcalcmypeptide.com

Frequently Asked Questions

What is Bonomarlot A-20 and what does it do?▼
Bonomarlot (A-20) is a natural peptide bioregulator derived from the bone marrow of young calves. It contains a complex of short peptides (<5 kDa) developed by Professor Vladimir Khavinson. It is designed to support the structural and functional health of bone marrow — the body's blood cell factory — helping maintain hematopoietic balance and immune resilience as we age.
Who should consider Bonomarlot?▼
Bonomarlot is most relevant for: (1) individuals over 40–50 experiencing age-related immune decline or fatigue; (2) those using it as part of a comprehensive anti-aging Cytomax stack; (3) people recovering from conditions that stress bone marrow (illness, heavy infections, cytotoxic therapies — but always physician-supervised for this use); (4) endurance athletes or high performers looking to support optimal blood cell production.
What peptides does Bonomarlot combine well with?▼
Per Khavinson's published protocols: for immune and detox support, pair with Vladonix (A-6, thymus), Svetinorm (A-7, liver), and Endoluten (A-8, neuro-endocrine). For cardiovascular support, add Ventfort (A-3, blood vessels). For locomotor recovery, add Sigumir (A-4, cartilage/bone). You can safely take up to 5 Cytomaxes simultaneously.
Does Bonomarlot contain actual bone marrow extract or hormones?▼
No hormones. Bonomarlot contains short-chain peptides (<5 kDa) extracted from bone marrow via patented cold filtration. This process removes DNA fragments, prions, and any immunogenic material. The result is a clean, targeted peptide complex — not a glandular supplement in the traditional sense, and completely distinct from erythropoietin or any growth factor.
How many capsules are in a box and how long does it last?▼
Bonomarlot is available in 20-capsule or 60-capsule boxes. At the standard 2 capsules/day protocol, a 20-capsule box = 10-day mini-course; a 60-capsule box = a full 30-day course. Khavinson recommends 2–3 full courses per year.

References

  1. Khavinson VKh “"Peptide bioregulators — a new class of geroprotectors".” Bulletin of Experimental Biology and Medicine (2002). PMID: 12677266
  2. Khavinson VKh, Anisimov VN “"Peptide regulation of aging".” Rejuvenation Research (2007). PMID: 17516852
  3. Khavinson VK, Morozov VG “"Regulatory peptides and the aging process".” Neuroendocrinology Letters (2003). PMID: 14618157

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