Hormone SupportAlso known as: KP-10, Metastin 45-54, KISS1 peptide
Kisspeptin-10
Endogenous neuropeptide that acts upstream of GnRH neurons — the master switch for puberty initiation and reproductive hormone cascade. Studied for IVF trigger and hypogonadotropic hypogonadism.
Half-Life
~3.6 minutes
Dose Range
0.3-1 nmol/kg IV bolus (research)
Frequency
Research protocol (IV infusion)
Vial Sizes
1 mg
Mechanism of Action
Acts on KISS1R (GPR54) on GnRH neurons in the arcuate and AVPV nuclei of the hypothalamus. Triggers GnRH pulsatile release which cascades to LH/FSH secretion. Loss-of-function mutations cause idiopathic hypogonadotropic hypogonadism.
Source: PMID: 15713786
Dosing Protocol
| Typical Dose | 0.3-1 nmol/kg IV bolus (research) |
| Frequency | Research protocol (IV infusion) |
| Half-Life | ~3.6 minutes |
| Common Vial Sizes | 1 mg |
Reconstitution Example
Vial
1 mg
Water
1 mL
Concentration
1 mg/mL
Per Unit (100u syringe)
10 mcg
Dose of 50 mcg = 5 units on a 100-unit insulin syringe
Dosing Quick Reference
Kisspeptin-10— Dosing Guide
Dose Range
0.3-1 nmol/kg IV bolus (research)
Half-Life
~3.6 minutes
Frequency
Research protocol (IV infusion)
Route
Subcutaneous
1 mg vial
💧 1 mL BAC water|📐 1 mg/mL concentration|💉 10 mcg/unit (100u syringe)
Hormone Supportcalcmypeptide.com
Looking for a trusted source? See our recommended suppliers →
Independently tested · COA-verified · Save 10% with our exclusive code