Cosmetic PeptideAlso known as: Pal-GHK, Biopeptide CL, collagen-boosting peptide
Palmitoyl Tripeptide-1
Lipidated tripeptide (Gly-His-Lys with palmitoyl chain) that mimics the matrikine signal fragment released during collagen degradation. Stimulates fibroblasts to produce new collagen I, III, and glycosaminoglycans.
Half-Life
~6-8 hours (topical, estimated)
Dose Range
100-500 ppm topical
Frequency
1-2× daily (topical)
Vial Sizes
N/A (oral)
Mechanism of Action
Acts as a matrikine mimic — the Gly-His-Lys sequence is recognized by fibroblast TGF-β receptors as a collagen breakdown signal. Triggers compensatory collagen synthesis, fibronectin production, and glycosaminoglycan deposition. The palmitoyl chain enhances skin penetration.
Source: PMID: 15709013
Dosing Protocol
| Typical Dose | 100-500 ppm topical |
| Frequency | 1-2× daily (topical) |
| Half-Life | ~6-8 hours (topical, estimated) |
Dosing Quick Reference
Palmitoyl Tripeptide-1— Dosing Guide
Dose Range
100-500 ppm topical
Half-Life
~6-8 hours (topical, estimated)
Frequency
1-2× daily (topical)
Route
Oral
Cosmetic Peptidecalcmypeptide.com
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