Clinical / PharmaceuticalAlso known as: Elmiron, PPS, SP-54, Cartrophen
Pentosan Polysulfate
Semi-synthetic heparinoid (Elmiron) — FDA-approved for interstitial cystitis. Also used veterinarily (Cartrophen) for osteoarthritis. Acts as a glycosaminoglycan replacement for damaged bladder and joint lining.
Half-Life
~4.8 hours
Dose Range
100 mg 3× daily (oral) or 2 mg/kg IM
Frequency
3× daily (oral) or 1-2× weekly (IM)
Vial Sizes
N/A (oral)
Mechanism of Action
Adheres to damaged uroepithelial glycosaminoglycan (GAG) layer, restoring the protective mucosal barrier in the bladder. Anti-inflammatory via inhibition of complement activation, coagulation cascades, and inflammatory mediators. Also inhibits fibroblast growth factor-mediated cartilage degradation.
Source: PMID: 2206774
Dosing Protocol
| Typical Dose | 100 mg 3× daily (oral) or 2 mg/kg IM |
| Frequency | 3× daily (oral) or 1-2× weekly (IM) |
| Half-Life | ~4.8 hours |
Dosing Quick Reference
Pentosan Polysulfate— Dosing Guide
Dose Range
100 mg 3× daily (oral) or 2 mg/kg IM
Half-Life
~4.8 hours
Frequency
3× daily (oral) or 1-2× weekly (IM)
Route
Oral
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