Weight ManagementAlso known as: Symlin, amylin analog, AC137
Pramlintide
Synthetic amylin analog (Symlin) — the only FDA-approved amylin-based drug. Used as adjunct to insulin in type 1 and type 2 diabetes. The forerunner to cagrilintide.
Half-Life
~48 minutes
Dose Range
15-120 mcg per meal
Frequency
3× daily (before meals)
Vial Sizes
0.6 mg, 1 mg
Mechanism of Action
Modified human amylin (pramlintide has Pro substitutions at positions 25, 28, 29 to prevent aggregation). Slows gastric emptying, suppresses post-prandial glucagon, and promotes CNS satiety via area postrema amylin receptors.
Source: FDA Label (Symlin), PMID: 15677783
Dosing Protocol
| Typical Dose | 15-120 mcg per meal |
| Frequency | 3× daily (before meals) |
| Half-Life | ~48 minutes |
| Common Vial Sizes | 0.6 mg, 1 mg |
Reconstitution Example
Vial
0.6 mg
Water
1 mL
Concentration
0.6 mg/mL
Per Unit (100u syringe)
6 mcg
Dose of 15 mcg = 2.5 units on a 100-unit insulin syringe
Dosing Quick Reference
Pramlintide— Dosing Guide
Dose Range
15-120 mcg per meal
Half-Life
~48 minutes
Frequency
3× daily (before meals)
Route
Subcutaneous
0.6 mg vial1 mg vial
💧 1 mL BAC water|📐 0.6 mg/mL concentration|💉 6 mcg/unit (100u syringe)
Weight Managementcalcmypeptide.com
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